Molecular weight (DA)
60kD
Immunogen
Synthesized peptide derived from human PGM1 AA range: 318-368
Specificity
This antibody detects endogenous levels of PGM1 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.98% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene is an isozyme of phosphoglucomutase (PGM) and belongs to the phosphohexose mutase family. There are several PGM isozymes, which are encoded by different genes and catalyze the transfer of phosphate between the 1 and 6 positions of glucose. In most cell types, this PGM isozyme is predominant, representing about 90% of total PGM activity. In red cells, PGM2 is a major isozyme. This gene is highly polymorphic. Mutations in this gene cause glycogen storage disease type 14. Alternativley spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Mar 2010],
Function
catalytic activity:Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.,cofactor:Binds 1 magnesium ion per subunit.,function:This enzyme participates in both the breakdown and synthesis of glucose.,polymorphism:Many polymorphic variants of PGM1 exist. 8 different alleles are known: PGM1*1+, PGM1*1-, PGM1*2+, PGM1*2-, PGM1*3+, PGM1*3-, PGM1*7+ and PGM1*7-. The sequence of PGM1*1+ is shown here.,similarity:Belongs to the phosphohexose mutase family.,subunit:Monomer.,
Other name
Phosphoglucomutase-1 (PGM 1) (EC 5.4.2.2) (Glucose phosphomutase 1)
Fields
>>Glycolysis / Gluconeogenesis;>>Pentose phosphate pathway;>>Galactose metabolism;>>Purine metabolism;>>Starch and sucrose metabolism;>>Amino sugar and nucleotide sugar metabolism;>>Metabolic pathways;>>Biosynthesis of nucleotide sugars
Human protein sequence Database
P36871
Mouse protein sequence database
Q9D0F9
Rat protein sequence database
P38652
Cellular localization
[Isoform 1]: Cytoplasm.
Tissue expression
Cervix,Epithelium,Hypothalamus,Placenta,Skeletal muscle,Skin,
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