Molecular weight (DA)
60kD
Immunogen
Synthesized peptide derived from human SPTC2 AA range: 273-323
Specificity
This antibody detects endogenous levels of SPTC2 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.100% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I. [provided by RefSeq, Mar 2011],
Function
catalytic activity:Palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO(2).,cofactor:Pyridoxal phosphate.,pathway:Lipid metabolism; sphingolipid metabolism.,similarity:Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.,subunit:SPTLC1, SPTLC2 and SPTLC3 may encode subunits of the enzyme.,tissue specificity:Widely expressed.,
Gene Name
SPTLC2 KIAA0526 LCB2
Other name
Serine palmitoyltransferase 2 (EC 2.3.1.50) (Long chain base biosynthesis protein 2) (LCB 2) (Long chain base biosynthesis protein 2a) (LCB2a) (Serine-palmitoyl-CoA transferase 2) (SPT 2)
Fields
>>Sphingolipid metabolism;>>Metabolic pathways;>>Sphingolipid signaling pathway
Human protein sequence Database
O15270
Mouse protein sequence database
P97363
Rat protein sequence database
Cellular localization
Endoplasmic reticulum membrane ; Single-pass membrane protein .
Tissue expression
Widely expressed.
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