Immunogen
Synthesized peptide derived from human C-ternal PANX1
Specificity
This antibody detects endogenous levels of PANX1 at Human, Mouse,Rat
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 IHC 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
Structural component of the gap junctions and the hemichannels involved in the ATP release and nucleotide permeation . May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis . Plays a critical role in oogenesis .
Gene Name
PANX1 MRS1 UNQ2529/PRO6028
Human protein sequence Database
Q96RD7
Mouse protein sequence database
Q9JIP4
Rat protein sequence database
P60570
Cellular localization
Cell membrane ; Multi-pass membrane protein . Cell junction, gap junction . Endoplasmic reticulum membrane ; Multi-pass membrane protein .
Tissue expression
Widely expressed (PubMed:30918116). Highest expression is observed in oocytes and brain (PubMed:30918116). Detected at very low levels in sperm cells (PubMed:30918116).