Molecular weight (DA)
65kD
Immunogen
Synthesized peptide derived from human EST3 AA range: 447-497
Specificity
This antibody detects endogenous levels of EST3 at Human
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.193% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene is expressed in several tissues, particularly in colon, trachea and in brain, and the protein participates in colon and neural drug metabolism. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported, but the biological validity and/or full-length nature of some variants have not been determined.[provided by RefSeq, Jun 2010],
Function
catalytic activity:A carboxylic ester + H(2)O = an alcohol + a carboxylate.,function:Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics.,PTM:N-glycosylated.,similarity:Belongs to the type-B carboxylesterase/lipase family.,tissue specificity:Expressed in liver, colon and small intestine.,
Gene Name
CES3 UNQ869/PRO1887
Other name
Carboxylesterase 3 (EC 3.1.1.1) (Liver carboxylesterase 31 homolog)
Human protein sequence Database
Q6UWW8
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Endoplasmic reticulum lumen .
Tissue expression
Expressed in liver, colon and small intestine.
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