Molecular weight (DA)
60kD
Immunogen
Synthesized peptide derived from human FBXW5 AA range: 319-369
Specificity
This antibody detects endogenous levels of FBXW5 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.132% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented. [provided by RefSeq, Jul 2008],
Function
function:Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.,similarity:Contains 1 F-box domain.,similarity:Contains 3 WD repeats.,subunit:Interacts with SKP1A and CUL1.,
Gene Name
FBXW5 FBW5 PP3971
Other name
F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5)
Human protein sequence Database
Q969U6
Mouse protein sequence database
Q9QXW2
Rat protein sequence database
Q4KLI9
Cellular localization
Cytoplasm .
Tissue expression
Brain,Cervix,Colon,Ovary,Placenta,Skin,Testis,
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