Molecular weight (DA)
60kD
Immunogen
Synthesized peptide derived from human SGPL1 AA range: 393-443
Specificity
This antibody detects endogenous levels of SGPL1 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.158% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
catalytic activity:Sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde.,cofactor:Pyridoxal phosphate.,function:Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis.,pathway:Lipid metabolism; sphingolipid metabolism.,similarity:Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.,tissue specificity:Found in liver and kidney.,
Other name
Sphingosine-1-phosphate lyase 1 (S1PL) (SP-lyase 1) (SPL 1) (hSPL) (EC 4.1.2.27) (Sphingosine-1-phosphate aldolase)
Fields
>>Sphingolipid metabolism;>>Metabolic pathways;>>Sphingolipid signaling pathway
Human protein sequence Database
O95470
Mouse protein sequence database
Q8R0X7
Rat protein sequence database
Q8CHN6
Cellular localization
Endoplasmic reticulum membrane ; Single-pass type III membrane protein ; Cytoplasmic side .
Tissue expression
Ubiquitously expressed (PubMed:11018465, PubMed:28165343). Expressed in fetal and adult adrenal gland (at protein level) (PubMed:28165343).
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