Molecular weight (DA)
60kD
Immunogen
Synthesized peptide derived from human FHR5 AA range: 353-403
Specificity
This antibody detects endogenous levels of FHR5 at Human
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.165% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties, a region within repeats 5-7 having heparin binding and C reactive protein binding properties, and the C-terminal repeats being similar to a complement component 3 b (C3b) binding domain. This protein co-localizes with C3, binds C3b in a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been associated, but not causally linked, with two different forms of kidney disease: membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS). [provided by RefSeq, Jan 2010],
Function
function:Involved in complement regulation.,similarity:Contains 9 Sushi (CCP/SCR) domains.,subunit:Binds C3b in vitro.,tissue specificity:Expressed by the liver and secreted in plasma.,
Gene Name
CFHR5 CFHL5 FHR5
Other name
Complement factor H-related protein 5 (FHR-5)
Fields
>>Complement and coagulation cascades
Human protein sequence Database
Q9BXR6
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Secreted.
Tissue expression
Expressed by the liver and secreted in plasma.
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