Molecular weight (DA)
65kD
Immunogen
Synthesized peptide derived from human S47A1 AA range: 158-208
Specificity
This antibody detects endogenous levels of S47A1 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.186% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene is located within the Smith-Magenis syndrome region on chromosome 17. It encodes a protein of unknown function. [provided by RefSeq, Jul 2008],
Function
function:Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes.,similarity:Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.,subcellular location:Predominantly localized at the plasma membrane but also found in intracellular organelles.,tissue specificity:Expressed in adrenal gland, and to a lower extent in liver, skeletal muscle and kidney (especially found in luminal membr
Other name
Multidrug and toxin extrusion protein 1 (MATE-1) (hMATE-1) (Solute carrier family 47 member 1)
Human protein sequence Database
Q96FL8
Mouse protein sequence database
Q8K0H1
Rat protein sequence database
Q5I0E9
Cellular localization
Cell membrane ; Multi-pass membrane protein . Predominantly localized at the plasma membrane but also found in intracellular organelles.
Tissue expression
Expressed in adrenal gland, and to a lower extent in liver, skeletal muscle and kidney (especially found in luminal membranes of the urinary tubules, bile caniculi and brush border membranes).
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