Immunogen
Synthesized peptide derived from human U17L2 AA range: 321-371
Specificity
This antibody detects endogenous levels of U17L2 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
DUB3 is a member of the ubiquitin processing protease (UBP) subfamily of deubiquitinating enzymes. See USP1 (MIM 603478) for background information.[supplied by OMIM, Mar 2008],
Function
catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,caution:The RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a copy of USP17. It is present with an interindividual variation in copy number and between 20 to 103 copies can be found both on chromosome 4 and chromosome 8.,caution:The RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a copy of USP17. It is present with an interindividual variation in copy number and between 20 to 103 copies can be found in the genome both on chromosome 4 and chromosome 8.,function:Functions in cell apoptosis. Cleaves ubiquitin fusion protein substrates.,function:Functions in cell apoptosis. Cleaves ubiquitin fusion protein substrates. May also bind hyaluronan and RNA.,induction:Up-regulated by interleukin-4 and interleukin-6 (
Human protein sequence Database
Q6R6M4
Mouse protein sequence database
Q7M764
Rat protein sequence database
Cellular localization
Nucleus . Endoplasmic reticulum .
Tissue expression
Broadly expressed.
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