Molecular weight (DA)
65kD
Immunogen
Synthesized peptide derived from human VPS45 AA range: 470-520
Specificity
This antibody detects endogenous levels of VPS45 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.188% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec1 domain family, and shows a high degree of sequence similarity to mouse, rat and yeast Vps45. The exact function of this gene is not known, but its high expression in peripheral blood mononuclear cells suggests a role in trafficking proteins, including inflammatory mediators. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013],
Function
function:May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network.,similarity:Belongs to the STXBP/unc-18/SEC1 family.,subcellular location:Associated with Golgi/endosomal vesicles and the trans-Golgi network.,subunit:Interacts with STX6 (By similarity). Interacts with ZFYVE20.,tissue specificity:Ubiquitous. Expression was highest in testis, heart and brain, intermediate in kidney, spleen, prostate, ovary, small intestine and thymus and low in lung, skeletal muscle, placenta, colon, pancreas, peripheral blood leukocytes and liver.,
Gene Name
VPS45 VPS45A VPS45B
Other name
Vacuolar protein sorting-associated protein 45 (h-VPS45) (hlVps45)
Human protein sequence Database
Q9NRW7
Mouse protein sequence database
P97390
Rat protein sequence database
O08700
Cellular localization
Golgi apparatus membrane ; Peripheral membrane protein . Endosome membrane ; Peripheral membrane protein . Associated with Golgi/endosomal vesicles and the trans-Golgi network. .
Tissue expression
Ubiquitous. Expression was highest in testis, heart and brain, intermediate in kidney, spleen, prostate, ovary, small intestine and thymus and low in lung, skeletal muscle, placenta, colon, pancreas, peripheral blood leukocytes and liver.
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