Molecular weight (DA)
67kD
Immunogen
Synthesized peptide derived from human TOM70
Specificity
This antibody detects endogenous levels of TOM70 at Human, Mouse,Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Function
Acts as receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex). Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner . Mediates TBK1 and IRF3 activation induced by MAVS in response to Sendai virus infection and promotes host antiviral responses during virus infection . Upon Sendai virus infection, recruits HSP90AA1:IRF3:BAX in mitochondrion and the complex induces apoptosis .
Gene Name
TOMM70A KIAA0719 TOM70
Protein name
Mitochondrial import receptor subunit TOM70 (Mitochondrial precursor proteins import receptor) (Translocase of outer membrane 70 kDa subunit)
Human protein sequence Database
O94826
Mouse protein sequence database
Q9CZW5
Rat protein sequence database
Q75Q39
Cellular localization
Mitochondrion outer membrane ; Single-pass membrane protein .
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
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