Molecular weight (DA)
105kD
Immunogen
Synthesized peptide derived from human MMRN2 AA range: 133-183
Specificity
This antibody detects endogenous levels of MMRN2 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.204% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a protein belonging to the member of elastin microfibril interface-located (EMILIN) protein family. This family member is an extracellular matrix glycoprotein that can interfere with tumor angiogenesis and growth. It serves as a transforming growth factor beta antagonist and can interfere with the VEGF-A/VEGFR2 pathway. A related pseudogene has been identified on chromosome 6. [provided by RefSeq, Aug 2012],
Function
PTM:N- and O-glycosylated.,similarity:Contains 1 C1q domain.,similarity:Contains 1 EMI domain.,subunit:Heteromer of p110, p125, p140 and p200 subunits; disulfide-linked.,tissue specificity:Endothelium.,
Other name
Multimerin-2 (EMILIN-3) (Elastin microfibril interface located protein 3) (Elastin microfibril interfacer 3) (EndoGlyx-1 p125/p140 subunit)
Human protein sequence Database
Q9H8L6
Mouse protein sequence database
A6H6E2
Rat protein sequence database
Cellular localization
Secreted, extracellular space, extracellular matrix .
Tissue expression
Endothelium.
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