Molecular weight (DA)
105kD
Immunogen
Synthesized peptide derived from human WDR36 AA range: 607-657
Specificity
This antibody detects endogenous levels of WDR36 at Human
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.219% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Mutations in this gene have been associated with adult-onset primary open-angle glaucoma (POAG). [provided by RefSeq, Jul 2008],
Function
disease:Defects in WDR36 are the cause of primary open angle glaucoma type 1G (GLC1G) [MIM:609887]. Primary open angle glaucoma (POAG) is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place.,function:Involved in T cell activation and highly co-regulated with IL2.,similarity:Contains 9 WD repeats.,tissue specificity:Expressed in heart, placenta, liver, skeletal muscle, kidney and pancreas. In ocular tissues, strong expression in iris, sclera, ciliary muscle, ciliary body, retina and optic nerve.,
Other name
WD repeat-containing protein 36 (T-cell activation WD repeat-containing protein) (TA-WDRP)
Fields
>>Ribosome biogenesis in eukaryotes
Human protein sequence Database
Q8NI36
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Nucleus, nucleolus .
Tissue expression
Expressed in heart, placenta, liver, skeletal muscle, kidney and pancreas. In ocular tissues, strong expression in iris, sclera, ciliary muscle, ciliary body, retina and optic nerve.
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