Molecular weight (DA)
105kD
Immunogen
Synthesized peptide derived from human NOD1 AA range: 290-340
Specificity
This antibody detects endogenous levels of NOD1 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.224% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the NOD (nucleotide-binding oligomerization domain) family. This member is a cytosolic protein. It contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid. Multiple alternatively spliced transcript variants differring in the 5' UTR have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Oct 2009],
Function
function:Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS).,similarity:Contains 1 CARD domain.,similarity:Contains 1 NACHT domain.,similarity:Contains 9 LRR (leucine-rich) repeats.,subunit:Self-associates. Binds to caspase-9 and RIPK2 by CARD-CARD interaction.,tissue specificity:Highly expressed in adult heart, skeletal muscle, pancreas, spleen and ovary. Also detected in placenta, lung, liver, kidney, thymus, testis, small intestine and colon.,
Other name
Nucleotide-binding oligomerization domain-containing protein 1 (Caspase recruitment domain-containing protein 4)
Fields
>>NOD-like receptor signaling pathway;>>Epithelial cell signaling in Helicobacter pylori infection;>>Shigellosis;>>Salmonella infection;>>Pertussis
Human protein sequence Database
Q9Y239
Mouse protein sequence database
Q8BHB0
Rat protein sequence database
Cellular localization
Cytoplasm. Cell membrane . Apical cell membrane. Basolateral cell membrane. Detected in the cytoplasm and at the cell membrane. Following bacterial infection, localizes to bacterial entry sites in the cell membrane. Recruited to the basolateral and apical membranes in polarized epithelial cells.
Tissue expression
Highly expressed in adult heart, skeletal muscle, pancreas, spleen and ovary. Also detected in placenta, lung, liver, kidney, thymus, testis, small intestine and colon.
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