Molecular weight (DA)
105kD
Immunogen
Synthesized peptide derived from human GRIK4 AA range: 466-516
Specificity
This antibody detects endogenous levels of GRIK4 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.239% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013],
Function
function:Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.,similarity:Belongs to the glutamate-gated ion channel (TC 1.A.10) family.,subunit:Forms a heteromeric channel with GRIK1 or GRIK3.,
Other name
Glutamate receptor, ionotropic kainate 4 (Excitatory amino acid receptor 1) (EAA1) (Glutamate receptor KA-1) (KA1)
Fields
>>Neuroactive ligand-receptor interaction;>>Glutamatergic synapse
Human protein sequence Database
Q16099
Mouse protein sequence database
Q8BMF5
Rat protein sequence database
Q01812
Cellular localization
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
Tissue expression
Hippocampus,Kidney,
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