Molecular weight (DA)
105kD
Immunogen
Synthesized peptide derived from human DRP2 AA range: 437-487
Specificity
This antibody detects endogenous levels of DRP2 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.245% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
Members of the dystrophin family of proteins perform a critical role in the maintenance of membrane-associated complexes at points of intercellular contact in vertebrate cells. The protein encoded by this gene is predicted to resemble certain short C-terminal isoforms of dystrophin and dystrophin-related protein 1 (DRP1 or utrophin). DRP2 is expressed principally in the brain and spinal cord. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010],
Function
function:Possibly involved in membrane-cytoskeleton interactions of the central nervous system.,similarity:Contains 1 WW domain.,similarity:Contains 1 ZZ-type zinc finger.,similarity:Contains 2 spectrin repeats.,tissue specificity:Brain and spinal cord; very low levels in eye, ovary, epididymis and testis; not in cardiac and skeletal muscle.,
Other name
Dystrophin-related protein 2 (DRP-2)
Human protein sequence Database
Q13474
Mouse protein sequence database
Q05AA6
Rat protein sequence database
Q9EPA0
Cellular localization
Cell junction, synapse, postsynaptic density . Cell projection, dendrite . Perikaryon . Cell membrane ; Peripheral membrane protein . Detected in Schwann cells at periaxonal myelin membranes. .
Tissue expression
Detected in fetal brain.
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