Molecular weight (DA)
105kD
Immunogen
Synthesized peptide derived from human ERC2 AA range: 368-418
Specificity
This antibody detects endogenous levels of ERC2 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.246% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a protein that belongs to the Rab3-interacting molecule (RIM)-binding protein family. Members of this protein family form part of the cytomatrix at the active zone (CAZ) complex and function as regulators of neurotransmitter release. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015],
Function
function:Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ.,sequence caution:Contaminating sequence. Sequence of unknown origin in the N-terminal part.,subcellular location:In neurons, localized to synapses, and colocalizes with PCLO. Localized to the active zone of presynaptic density.,subunit:Interacts with BSN, ERC1, PPFIA1, PPFIA2, PPFIA3 and PPFIA4. Interacts through its C-terminus with the PDZ domain of RIMS1. Part of a complex consisting of ERC2, RIMS1 and UNC13A.,
Human protein sequence Database
O15083
Mouse protein sequence database
Q6PH08
Rat protein sequence database
Q8K3M6
Cellular localization
Cytoplasm . Cell junction, synapse . Cell junction, synapse, presynaptic active zone . Cytoplasm, cytoskeleton . In neurons, localized to synapses, and colocalizes with PCLO. Localized to the active zone of presynaptic density (By similarity). .
Tissue expression
Brain,Epithelium,PNS,
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