Immunogen
Synthesized peptide derived from human ROP1A AA range: 85-135
Specificity
This antibody detects endogenous levels of ROP1A at Human
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene is found in the fibrous sheath of spermatazoa, where it interacts with rhophilin, a Rho GTPase binding protein. The encoded protein also can bind an A-kinase anchoring protein (AKAP110) and a calcium-binding tyrosine phosphorylation-regulated protein (CABYR). This protein may be involved in sperm motility and has been shown to be a cancer-testis antigen in hematologic malignancies. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015],
Function
developmental stage:Expressed in fetal liver.,domain:The RIIa domain mediates interaction with AKAP3.,miscellaneous:The name 'ropporin' comes from the Japanese word 'oppo' which means 'tail'.,similarity:Belongs to the ropporin family.,similarity:Contains 1 RIIa domain.,subcellular location:In the sperm tail, found in the principal piece and in the cytoplasmic droplet located at the distal end of the midpiece. Inner surface of the fibrous sheath.,subunit:Homodimer. Interacts with AKAP3 and RHPN1 (By similarity). May interact with SPA17.,tissue specificity:Testis specific in adult. Overexpressed in hematologic tumor cells.,
Human protein sequence Database
Q9HAT0
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cell projection, cilium, flagellum . In the sperm tail, found in the principal piece and in the cytoplasmic droplet located at the distal end of the midpiece. Inner surface of the fibrous sheath. .
Tissue expression
Testis specific in adult. Overexpressed in hematologic tumor cells.
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