Molecular weight (DA)
105kD
Immunogen
Synthesized peptide derived from human KIF5C AA range: 119-169
Specificity
This antibody detects endogenous levels of KIF5C at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.247% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene is a kinesin heavy chain subunit involved in the transport of cargo within the central nervous system. The encoded protein, which acts as a tetramer by associating with another heavy chain and two light chains, interacts with protein kinase CK2. Mutations in this gene have been associated with complex cortical dysplasia with other brain malformations-2. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Jul 2015],
Function
domain:Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles.,function:Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport.,similarity:Belongs to the kinesin-like protein family.,similarity:Belongs to the kinesin-like protein family. Kinesin subfamily.,similarity:Contains 1 kinesin-motor domain.,subunit:Oligomer composed of two heavy chains and two light chains. Interacts with GRIP1 and KLC3.,tissue specificity:Highest expression in brain, prostate and testis, and moderate expression in kidney
Gene Name
KIF5C KIAA0531 NKHC2
Other name
Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific 2)
Fields
>>Endocytosis;>>Dopaminergic synapse;>>Alzheimer disease;>>Parkinson disease;>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Prion disease;>>Pathways of neurodegeneration - multiple diseases;>>Salmonella infection;>>Non-small cell lung cancer
Human protein sequence Database
O60282
Mouse protein sequence database
P28738
Rat protein sequence database
P56536
Cellular localization
Cytoplasm, cytoskeleton . Cell projection, dendrite . Abundant in distal regions of dendrites. .
Tissue expression
Highest expression in brain, prostate and testis, and moderate expression in kidney, small intestine and ovary.
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