Immunogen
Synthesized peptide derived from human N-ternal UBL4A
Specificity
This antibody detects endogenous levels of UBL4A at Human, Mouse,Rat
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 IHC 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation . The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum . Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome . Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the
Gene Name
UBL4A DXS254E GDX UBL4
Protein name
Ubiquitin-like protein 4A (Ubiquitin-like protein GDX)
Other name
Ubiquitin-like protein 4A (Ubiquitin-like protein GDX)
Human protein sequence Database
P11441
Mouse protein sequence database
P21126
Rat protein sequence database
B2GV38
Cellular localization
Cytoplasm, cytosol . Nucleus .
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