Molecular weight (DA)
105kD
Immunogen
Synthesized peptide derived from human RUBIC AA range: 868-918
Specificity
This antibody detects endogenous levels of RUBIC at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.290% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene is a negative regulator of autophagy and endocytic trafficking and controls endosome maturation. This protein contains two conserved domains, an N-terminal RUN domain and a C-terminal DUF4206 domain. The RUN domain is involved in Ras-like GTPase signaling, and the DUF4206 domain contains a diacylglycerol (DAG) binding-like motif. Mutation in this gene results in deletion of the DAG binding-like motif and causes a recessive ataxia. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014],
Function
similarity:Contains 1 RUN domain.,
Other name
Run domain Beclin-1 interacting and cystein-rich containing protein (Rubicon) (Beclin-1 associated RUN domain containing protein) (Baron)
Fields
>>Autophagy - animal
Human protein sequence Database
Q92622
Mouse protein sequence database
Q80U62
Rat protein sequence database
Cellular localization
Late endosome . Lysosome . Early endosome . Predominantly located in late endosomes/lysosomes, only partially detected in early endosome and not at all in the Golgi apparatus.
Tissue expression
Blood,Bone marrow,Heart,Kidney,
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