Immunogen
Synthesized peptide derived from human KLK10 AA range: 199-249
Specificity
This antibody detects endogenous levels of KLK10 at Human/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008],
Function
developmental stage:Down-regulated during breast cancer progression.,function:Has a tumor-suppressor role for NES1 in breast and prostate cancer.,similarity:Belongs to the peptidase S1 family.,similarity:Belongs to the peptidase S1 family. Kallikrein subfamily.,similarity:Contains 1 peptidase S1 domain.,tissue specificity:Expressed in breast, ovary and prostate.,
Gene Name
KLK10 NES1 PRSSL1
Human protein sequence Database
O43240
Mouse protein sequence database
Rat protein sequence database
P36375
Cellular localization
Secreted .
Tissue expression
Expressed in breast, ovary and prostate.
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