Molecular weight (DA)
85kD
Immunogen
Synthesized peptide derived from human SATB1 AA range: 343-393
Specificity
This antibody detects endogenous levels of SATB1 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.302% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a matrix protein which binds nuclear matrix and scaffold-associating DNAs through a unique nuclear architecture. The protein recruits chromatin-remodeling factors in order to regulate chromatin structure and gene expression. [provided by RefSeq, Apr 2016],
Function
function:Binds to DNA at special AT-rich sequences at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA.,PTM:Sumoylated.,similarity:Belongs to the CUT homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,similarity:Contains 2 CUT DNA-binding domains.,tissue specificity:Expressed predominantly in thymus.,
Other name
DNA-binding protein SATB1 (Special AT-rich sequence-binding protein 1)
Human protein sequence Database
Q01826
Mouse protein sequence database
Q60611
Rat protein sequence database
Cellular localization
Nucleus matrix . Nucleus, PML body . Organized into a cage-like network anchoring loops of heterochromatin and tethering specialized DNA sequences (PubMed:12692553). When sumoylated, localized in promyelocytic leukemia nuclear bodies (PML NBs) (PubMed:18408014). .
Tissue expression
Expressed predominantly in thymus.
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