Molecular weight (DA)
85kD
Immunogen
Synthesized peptide derived from human ZDHC8 AA range: 289-339
Specificity
This antibody detects endogenous levels of ZDHC8 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.310% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a four transmembrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein may function as a palmitoyltransferase. Defects in this gene may be associated with a susceptibility to schizophrenia. Alternate splicing of this gene results in multiple transcript variants. A pseudogene of this gene is found on chromosome 22.[provided by RefSeq, May 2010],
Function
catalytic activity:Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA.,disease:According to PubMed:15489219 and PubMed:15184899, defects in ZDHHC8 may contribute to susceptibility to schizophrenia, but according to PubMed:15992527, PubMed:15631889 and PubMed:16150541, it is not the case.,domain:The DHHC domain is required for palmitoyltransferase activity.,function:Putative palmitoyltransferase involved in glutamatergic transmission.,similarity:Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.,similarity:Contains 1 DHHC-type zinc finger.,
Gene Name
ZDHHC8 KIAA1292 ZDHHCL1 ZNF378
Other name
Probable palmitoyltransferase ZDHHC8 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378)
Human protein sequence Database
Q9ULC8
Mouse protein sequence database
Q5Y5T5
Rat protein sequence database
Cellular localization
Golgi apparatus membrane ; Multi-pass membrane protein . Mitochondrion membrane ; Multi-pass membrane protein .
Tissue expression
Widely expressed.
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