Molecular weight (DA)
85kD
Immunogen
Synthesized peptide derived from human TTLL3 AA range: 357-407
Specificity
This antibody detects endogenous levels of TTLL3 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.344% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
function:Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.,similarity:Belongs to the ARPC4 family.,similarity:Contains 1 TTL domain.,subunit:Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.,
Other name
Tubulin monoglycylase TTLL3 (EC 6.3.2.-) (HOTTL) (Tubulin--tyrosine ligase-like protein 3)
Human protein sequence Database
Q9Y4R7
Mouse protein sequence database
A4Q9E5
Rat protein sequence database
Cellular localization
Cytoplasm, cytoskeleton . Cell projection, cilium . Cytoplasm, cytoskeleton, cilium axoneme . Cytoplasm, cytoskeleton, flagellum axoneme .
Tissue expression
Expressed in brain, heart, kidney, testis, liver, lung, muscle, spleen, trachea and colon.