Molecular weight (DA)
85kD
Immunogen
Synthesized peptide derived from human CNNM4 AA range: 18-68
Specificity
This antibody detects endogenous levels of CNNM4 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.358% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the ancient conserved domain containing protein family. Members of this protein family contain a cyclin box motif and have structural similarity to the cyclins. The encoded protein may play a role in metal ion transport. Mutations in this gene are associated with Jalili syndrome which consists of cone-rod dystrophy and amelogenesis imperfecta. [provided by RefSeq, Feb 2010],
Function
function:Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions.,miscellaneous:Shares weak sequence similarity with the cyclin family, explaining its name. However it has no cyclin-like function in vivo.,similarity:Belongs to the ACDP family.,similarity:Contains 2 CBS domains.,subunit:Interacts with COX11.,tissue specificity:Widely expressed. Highly expressed in heart.,
Gene Name
CNNM4 ACDP4 KIAA1592
Other name
Metal transporter CNNM4 (Ancient conserved domain-containing protein 4) (Cyclin-M4)
Human protein sequence Database
Q6P4Q7
Mouse protein sequence database
Q69ZF7
Rat protein sequence database
P0C588
Cellular localization
Cell membrane ; Multi-pass membrane protein .
Tissue expression
Widely expressed. Highly expressed in heart.
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