Immunogen
Synthesized peptide derived from human ADH4 AA range: 6-56
Specificity
This antibody detects endogenous levels of ADH4 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes. [provided by RefSeq, Jul 2008],
Function
catalytic activity:An alcohol + NAD(+) = an aldehyde or ketone + NADH.,cofactor:Binds 2 zinc ions per subunit.,miscellaneous:There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.,similarity:Belongs to the zinc-containing alcohol dehydrogenase family. Class-II subfamily.,subunit:Homodimer.,
Fields
>>Glycolysis / Gluconeogenesis;>>Fatty acid degradation;>>Tyrosine metabolism;>>Pyruvate metabolism;>>Retinol metabolism;>>Metabolism of xenobiotics by cytochrome P450;>>Drug metabolism - cytochrome P450;>>Metabolic pathways;>>Alcoholic liver disease
Human protein sequence Database
P08319
Mouse protein sequence database
Q9QYY9
Rat protein sequence database
Q64563
Cellular localization
Cytoplasm.
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