Immunogen
Synthesized peptide derived from human FOXG1 AA range: 247-297
Specificity
This antibody detects endogenous levels of FOXG1 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This locus encodes a member of the forked-head transcription factor family. The encoded protein, which functions as a repressor, may play a role in brain development. Mutations at this locus have been associated with Rett syndrome. [provided by RefSeq, Feb 2012],
Function
caution:PubMed:7959731 claims that there are 3 different FOXG1 proteins, FOXG1A, FOXG1B, and FOXG1C. It was latter found that there is only one gene and the differences between these three may be sequencing errors since the protein is coded in a unique exon.,function:Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon.,similarity:Contains 1 fork-head DNA-binding domain.,subunit:Interacts with KDM5B.,tissue specificity:Expression is restricted to the neurons of the developing telencephalon.,
Gene Name
FOXG1 FKH2 FKHL1 FKHL2 FKHL3 FKHL4 FOXG1A FOXG1B FOXG1C
Fields
>>FoxO signaling pathway
Human protein sequence Database
P55316
Mouse protein sequence database
Q60987
Rat protein sequence database
Q00939
Cellular localization
Nucleus .
Tissue expression
Expression is restricted to the neurons of the developing telencephalon.
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