Immunogen
Synthesized peptide derived from human HDBP1 AA range: 1-51
Specificity
This antibody detects endogenous levels of HDBP1 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a capillary endothelial cell protein that facilitates the lipolytic processing of triglyceride-rich lipoproteins. The encoded protein is a glycosylphosphatidylinositol-anchored protein that is a member of the lymphocyte antigen 6 (Ly6) family. This protein plays a major role in transporting lipoprotein lipase (LPL) from the subendothelial spaces to the capillary lumen. Mutations in this gene are the cause of hyperlipoproteinemia, type 1D. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014],
Function
caution:The mouse ortholog has been suggested to be a GPI-anchored protein, but no GPI-anchor is detected by prediction methods.,function:Plays a key role in the lipolytic processing of chylomicrons.,polymorphism:The missense variant Arg-56 may be associated with severe hypertriglyceridemia and chylomicronemia.,similarity:Contains 1 UPAR/Ly6 domain.,subcellular location:Localized at the cell surface.,subunit:Binds with high affinity to high-density lipoprotein (HDL) (By similarity). Binds to lipoprotein lipase (LPL), chylomicrons and APOA5.,
Human protein sequence Database
Q8IV16
Mouse protein sequence database
Q9D1N2
Rat protein sequence database
Cellular localization
Apical cell membrane ; Lipid-anchor, GPI-anchor . Basolateral cell membrane ; Lipid-anchor, GPI-anchor . Cell membrane ; Lipid-anchor, GPI-anchor .
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