Immunogen
Synthesized peptide derived from human LPP3 AA range: 205-255
Specificity
This antibody detects endogenous levels of LPP3 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is a membrane glycoprotein localized at the cell plasma membrane. It has been shown to actively hydrolyze extracellular lysophosphatidic acid and short-chain phosphatidic acid. The expression of this gene is found to be enhanced by epidermal growth factor in Hela cells. [provided by RefSeq, Mar 2010],
Function
catalytic activity:A 3-sn-phosphatidate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate.,enzyme regulation:Inhibited by sphingosine, zinc ions and propanolol. Not inhibited by N-ethylmaleimide treatment.,function:Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA = PA > C-1-P > S-1-P. May be involved in cell adhesion and in cell-cell interactions.,induction:By epidermal growth factor (EGF), vascular endothelial growrh factor (VEGF), basic fibroblast growth factor (bFGF) and phorbol myristate acetate (PMA).,PTM:N-glycosylated. Contains high-mannose oligosaccharides.,similarity:Belongs to the PA-phosphatase related phosphoesterase family.,subunit:Homodimer. This complex seems not to be involved in substrate
Fields
>>Glycerolipid metabolism;>>Glycerophospholipid metabolism;>>Ether lipid metabolism;>>Sphingolipid metabolism;>>Metabolic pathways;>>Phospholipase D signaling pathway;>>Fc gamma R-mediated phagocytosis;>>Fat digestion and absorption;>>Choline metabolism in cancer
Human protein sequence Database
O14495
Mouse protein sequence database
Q99JY8
Rat protein sequence database
P97544
Cellular localization
Cell membrane ; Multi-pass membrane protein . Basolateral cell membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Endoplasmic reticulum-Golgi intermediate compartment membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein . Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein . Membrane raft ; Multi-pass membrane protein . Cycles between the endoplasmic reticulum and the Golgi. .
Tissue expression
Ubiquitously expressed (PubMed:9305923, PubMed:12660161). Highly expressed in heart and placenta (PubMed:9305923).
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