Immunogen
Synthesized peptide derived from human ANR11 AA range: 557-607
Specificity
This antibody detects endogenous levels of ANR11 at Human
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1：50-200. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This locus encodes an ankryin repeat domain-containing protein. The encoded protein inhibits ligand-dependent activation of transcription. Mutations in this gene have been associated with KBG syndrome, which is characterized by macrodontia, distinctive craniofacial features, short stature, skeletal anomalies, global developmental delay, seizures and intellectual disability. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 2 and X. [provided by RefSeq, Jan 2012],
Function
function:May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Contains 4 ANK repeats.,subunit:Interacts with the PAS region of the p160 coactivators.,
Human protein sequence Database
Q6UB99
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Nucleus . Localizes to chromatin during prometaphase. .
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