Immunogen
Synthesized peptide derived from human FOXP4 AA range: 307-357
Specificity
This antibody detects endogenous levels of FOXP4 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Many members of the forkhead box gene family, including members of subfamily P, have roles in mammalian oncogenesis. This gene may play a role in the development of tumors of the kidney and larynx. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. [provided by RefSeq, Jul 2008],
Function
domain:The leucine-zipper is required for dimerization and transcriptional repression.,function:Transcriptional repressor that represses lung-specific expression.,similarity:Contains 1 C2H2-type zinc finger.,similarity:Contains 1 fork-head DNA-binding domain.,subunit:Forms homodimers and heterodimers with FOXP1 and FOXP2. Dimerization is required for DNA-binding.,
Human protein sequence Database
Q8IVH2
Mouse protein sequence database
Q9DBY0
Rat protein sequence database
Cellular localization
Nucleus .
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