Immunogen
Synthesized peptide derived from human SNAPN AA range: 9-59
Specificity
This antibody detects endogenous levels of SNAPN at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene is a coiled-coil-forming protein that associates with the SNARE (soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor) complex of proteins and the BLOC-1 (biogenesis of lysosome-related organelles) complex. Biochemical studies have identified additional binding partners. As part of the SNARE complex, it is required for vesicle docking and fusion and regulates neurotransmitter release. The BLOC-1 complex is required for the biogenesis of specialized organelles such as melanosomes and platelet dense granules. Mutations in gene products that form the BLOC-1 complex have been identified in mouse strains that are models of Hermansky-Pudlak syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012],
Function
function:May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release by potentiating the interaction of synaptotagmins with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells.,PTM:Phosphorylated.,subcellular location:May be cytoplasmic and peripheral membrane bound or anchored to the vesicular membrane through an N-terminal signal anchor.,subunit:Associates with the SNARE complex. Interacts with SNAP23, SNAP25 and STX4A but not with STX1A, VAMP2 and SYT1. Phosphorylation increases its interaction with SNAP25 (By similarity). Interacts with RGS7. Component of the biogenesis of lysosome-related organelles (BLOC-1) complex which is req
Gene Name
SNAPIN SNAP25BP SNAPAP
Human protein sequence Database
O95295
Mouse protein sequence database
Q9Z266
Rat protein sequence database
P60192
Cellular localization
Membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytosol . Cytoplasm, perinuclear region . Golgi apparatus membrane . Lysosome membrane . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane . Colocalizes with NANOS1 and PUM2 in the perinuclear region of germ cells. .
Tissue expression
Expressed in male germ cells of adult testis (at protein level).
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