Immunogen
Synthesized peptide derived from human CDRT1 AA range: 364-414
Specificity
This antibody detects endogenous levels of CDRT1 at Human
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008],
Function
miscellaneous:CDRT1 gene is located centromeric to and partially within proximal CMT1A-REP element. CMT1A-REP is a complex binary repeat element flanking a 1.5-Mb DNA region duplicated in Charcot-Marie-Tooth disease type I (CMT1A) or deleted in Hereditary neuropathy (HNPP).,similarity:Contains 4 WD repeats.,tissue specificity:Expressed in pancreas, heart and skeletal muscle.,
Gene Name
CDRT1 C17orf1 C17orf1A HREP
Human protein sequence Database
O95170
Mouse protein sequence database
Rat protein sequence database
Cellular localization
intracellular,
Tissue expression
Expressed in pancreas, heart and skeletal muscle.
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