Immunogen
Synthesized peptide derived from human HIP1R AA range: 554-604
Specificity
This antibody detects endogenous levels of HIP1R at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
domain:The talin-like domain binds F-actin.,function:Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis.,similarity:Belongs to the SLA2 family.,similarity:Contains 1 ENTH (epsin N-terminal homology) domain.,similarity:Contains 1 I/LWEQ domain.,subcellular location:Membrane-associated protein, mainly localized at the endocytic compartments and in the perinuclear region.,subunit:Interacts with actin. Does not interact with huntingtin (By similarity). Interacts with CLTB and HIP1.,tissue specificity:Brain, heart, kidney, pancreas, and liver, but not in lung or placenta.,
Gene Name
HIP1R HIP12 KIAA0655
Human protein sequence Database
O75146
Mouse protein sequence database
Q9JKY5
Rat protein sequence database
Cellular localization
Cytoplasm, perinuclear region. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Membrane-associated protein, mainly localized at the endocytic compartments and in the perinuclear region.
Tissue expression
Brain, heart, kidney, pancreas, and liver, but not in lung or placenta.
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