Immunogen
Synthesized peptide derived from human POLD4 AA range: 43-93
Specificity
This antibody detects endogenous levels of human POLD4
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Background
This gene encodes the smallest subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein enhances the activity of DNA polymerase delta and plays a role in fork repair and stabilization through interactions with the DNA helicase Bloom syndrome protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012],
Function
function:Required for optimal DNA polymerase delta activity. May contribute to PCNA-dependent activity of DNA polymerase delta.,similarity:Belongs to the DNA polymerase delta subunit 4 family.,subunit:Heterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa and 12 kDa. Interacts with WRNIP1. Interacts with POLD4, POLD2, POLD1 and PCNA.,
Other name
DNA polymerase delta subunit 4 (DNA polymerase delta subunit p12)
Fields
>>DNA replication;>>Base excision repair;>>Nucleotide excision repair;>>Mismatch repair;>>Homologous recombination
Human protein sequence Database
Q9HCU8
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Nucleus . Partially recruited to DNA damage sites within 2 hours following UV irradiation, before degradation. .
Tissue expression
Brain,Cervix,Ovarian carcinoma,Pooled,
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