Immunogen
Synthesized peptide derived from human ROM1 AA range: 163-213
Specificity
This antibody detects endogenous levels of ROM1 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene is a member of a photoreceptor-specific gene family and encodes an integral membrane protein found in the photoreceptor disk rim of the eye. This protein can form homodimers or can heterodimerize with another photoreceptor, retinal degeneration slow (RDS). It is essential for disk morphogenesis, and may also function as an adhesion molecule involved in the stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. Certain defects in this gene have been associated with the degenerative eye disease retinitis pigmentosa. [provided by RefSeq, Jul 2008],
Function
disease:Defects in ROM1 may cause retinitis pigmentosa (RP) [MIM:268000]; when associated with defects in PRPH2.,function:May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis.,online information:Retina International's Scientific Newsletter,similarity:Belongs to the PRPH2/ROM1 family.,subunit:Homodimer; disulfide-linked. Probably forms a complex with a PRPH2 homodimer. Other proteins could associate with this complex in rods.,tissue specificity:Retina (photoreceptor). In rim region of ROS (rod outer segment) disks.,
Human protein sequence Database
Q03395
Mouse protein sequence database
P32958
Rat protein sequence database
Q5PPM7
Cellular localization
Photoreceptor inner segment membrane ; Multi-pass membrane protein . Photoreceptor outer segment membrane ; Multi-pass membrane protein .
Tissue expression
Retina photoreceptors (at protein level) (PubMed:1610568, PubMed:8504299). In rim region of ROS disks (PubMed:1610568).
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