Molecular weight (DA)
85kD
Immunogen
Synthesized peptide derived from human AF1L1 AA range: 180-230
Specificity
This antibody detects endogenous levels of AF1L1 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.325% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 2 PH domains.,
Other name
Actin filament-associated protein 1-like 1 (AFAP1-like protein 1)
Human protein sequence Database
Q8TED9
Mouse protein sequence database
Q8BZI0
Rat protein sequence database
D4AB98
Cellular localization
Cytoplasm . Cell projection, podosome . Cell projection, invadopodium . Cytoplasm, cytoskeleton, stress fiber .
Tissue expression
Expressed in breast, colon and brain. In all 3 tissues, expressed in the microvasculature (at protein level). In addition, in the breast, found in the contractile myoepithelial cell layer which surrounds the breast ducts (at protein level). In the colon, expressed in the mucous membrane and colonic crypts and in the smooth muscle cell layer which provide movement of the colon (at protein level). In the cerebellum, localized around the Purkinje neurons and the granule cells of the granular layer, but not inside cell bodies (at protein level). Outside of the cerebellar cortex, expressed in glial cells (at protein level). Highly expressed away from the cell bodies within the dentate nucleus (at protein level).
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