Immunogen
Synthesized peptide derived from human S22AG AA range: 49-99
Specificity
This antibody detects endogenous levels of S22AG at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the organic zwitterion transporter protein family which transports carnitine. The encoded protein has also been shown to transport anticancer drugs like bleomycin (PMID: 20037140) successful treatment has been correlated with the level of activity of this transporter in tumor cells. [provided by RefSeq, Dec 2011],
Function
function:High affinity carnitine transporter; the uptake is partially sodium-ion dependent. Thought to mediate the L-carnitine secretion mechanism from testis epididymal epithelium into the lumen which is involved in the maturation of spermatozoa. Also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. The uptake of TEA is inhibited by various organic cations. The uptake of doxorubicin is sodium-independent.,similarity:Belongs to the major facilitator superfamily. Organic cation transporter family.,subcellular location:Detected in the plasma mebrane of Sertoli cells and in the luminal membrane of epithelial cells in the epididymus.,tissue specificity:Widely expressed at low levels in adult tissues and fetal brain, lung, liver and kidney. Expressed in testis and epididymus (at protein level). Expressed at lower levels in bone marrow and fetal liver. Expressed in
Human protein sequence Database
Q86VW1
Mouse protein sequence database
Q497L8
Rat protein sequence database
Cellular localization
Membrane ; Multi-pass membrane protein . Cell membrane . Detected in the plasma membrane of Sertoli cells and in the luminal membrane of epithelial cells in the epididymis.
Tissue expression
Widely expressed at low levels in adult tissues and fetal brain, lung, liver and kidney. Expressed in testis and epididymis (at protein level). Expressed at lower levels in bone marrow and fetal liver. Expressed in hematopoietic cells, including CD34(+) leukocytes and leukemia cells. Abundantly expressed in ovarian cancer clear-cell adenocarcinoma. Expressed in endometrium (at protein level); highly expressed during the normal secretory phase, but expression is significantly reduced in the proliferative phase.
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