Immunogen
Synthesized peptide derived from human VPS18 AA range: 778-828
Specificity
This antibody detects endogenous levels of VPS18 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps18 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. [provided by RefSeq, Jul 2008],
Function
function:May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes.,similarity:Belongs to the VPS18 family.,similarity:Contains 1 clathrin repeat.,similarity:Contains 1 RING-type zinc finger.,subcellular location:Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes.,subunit:Interacts with HOOK1 (By similarity). Large hetero-oligomeric complex together with VPS11, VPS16 and VPS33A. Interacts with STX7.,tissue specificity:Ubiquitous. Expression was highest in heart and low in lung.,
Fields
>>Salmonella infection
Human protein sequence Database
Q9P253
Mouse protein sequence database
Q8R307
Rat protein sequence database
Cellular localization
Late endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Lysosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Early endosome . Cytoplasmic vesicle, autophagosome . Cytoplasmic vesicle, clathrin-coated vesicle . Cytoplasmic, peripheral membrane protein associated with early endosomes and late endosomes/lysosomes.
Tissue expression
Ubiquitous. Expression was highest in heart and low in lung.
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