Molecular weight (DA)
46kD
Immunogen
Synthesized peptide derived from human GSDMB
Specificity
This antibody detects endogenous levels of GSDMB at Human
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Function
[Gasdermin-B]: Precursor of a pore-forming protein that acts as a downstream mediator of granzyme-mediated cell death . This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-B, N-terminal) binds to membranes and forms pores, triggering pyroptosis . ; [Gasdermin-B, N-terminal]: Pore-forming protein produced by cleavage by granzyme A (GZMA), which causes membrane permeabilization and pyroptosis in target cells of cytotoxic T and natural killer (NK) cells . Key downstream mediator of granzyme-mediated cell death: (1) granzyme A (GZMA), delivered to target cells from cytotoxic T- and NK-cells, (2) specifically cleaves Gasdermin-B to generate this form . After cleavage, moves to the plasma membrane, homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis . Binds
Gene Name
GSDMB GSDML PP4052 PRO2521
Protein name
Gasdermin-B (Gasdermin-like protein)
Human protein sequence Database
Q8TAX9
Mouse protein sequence database
Rat protein sequence database
Cellular localization
[Gasdermin-B]: Cytoplasm . Vesicular localization in the apical region of gastric chief cells and colonic surface mucous cells, and the basal region of neuroendocrine cells. .; [Gasdermin-B, N-terminal]: Cell membrane ; Multi-pass membrane protein .
Tissue expression
In the gastrointestinal tract, expressed in proliferating cells, including in the basal cell layer of esophagus and in isthmus/neck of stomach.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
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