Immunogen
Synthesized peptide derived from human MS4A3 AA range: 101-151
Specificity
This antibody detects endogenous levels of MS4A3 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the membrane-spanning 4A gene family. Members of this protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member likely plays a role in signal transduction and may function as a subunit associated with receptor complexes. The gene encoding this protein is localized to 11q12, among a cluster of related family members. Alternative splicing may result in multiple transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008],
Function
caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,domain:The C-terminal region is required for binding to CDKN3-CDK2 complexes and the modulation of CDKN3 activity.,function:Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin-dependent kinase 2 (CDK2) through its direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP).,similarity:Belongs to the MS4A family.,subcellular location:Located in the perinuclear area.,subunit:Interacts with CDKN3. Interacts with CDKN3-CDK2 complexes through its binding to CDKN3; this interaction facilitates dissociation of cyclin A from CDKN3-CDK2 complexes.,tissue specificity:Expressed specifically in hematopoietic cells and tissues.,
Gene Name
MS4A3 CD20L HTM4
Human protein sequence Database
Q96HJ5
Mouse protein sequence database
Q920C4
Rat protein sequence database
Cellular localization
Endomembrane system ; Multi-pass membrane protein . Cytoplasm, perinuclear region . Located in the perinuclear area.
Tissue expression
Expressed specifically in hematopoietic cells and tissues.
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