Immunogen
Synthesized peptide derived from human SDPR AA range: 129-179
Specificity
This antibody detects endogenous levels of SDPR at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a calcium-independent phospholipid-binding protein whose expression increases in serum-starved cells. This protein is a substrate for protein kinase C (PKC) phosphorylation and recruits polymerase I and transcript release factor (PTRF) to caveolae. Removal of this protein causes caveolae loss and its over-expression results in caveolae deformation and membrane tubulation.[provided by RefSeq, Sep 2009],
Function
function:May play a role in targeting PRKCA to caveolae.,induction:Up-regulated in asyncronously growing fibroblasts following serum deprivation but not following contact inhibition. Down-regulated during synchronous cell cycle re-entry.,miscellaneous:Binds phosphatidylserine (PS) in a calcium-independent manner. PS-binding is inhibited by phosphotidic acid and phosphatidylinositol. Does not bind phosphatidylcholine.,PTM:Phosphorylated on Ser residues.,PTM:The N-terminus is blocked.,similarity:Belongs to the PTRF/SDPR family.,subcellular location:Colocalizes with CAV1 to caveolae.,subunit:Binds to PRKCA in the presence of phosphatidylserine (By similarity). Interacts with MURC; this augments the transactivation of NPPA by MURC.,tissue specificity:Highly expressed in heart and lung, and expressed at lower levels in brain, kidney, liver, pancreas, placenta, and skeletal muscle.,
Human protein sequence Database
O95810
Mouse protein sequence database
Q63918
Rat protein sequence database
Q66H98
Cellular localization
Cytoplasm, cytosol . Membrane, caveola . Localizes in the caveolae in a caveolin-dependent manner. .
Tissue expression
Highly expressed in heart and lung, and expressed at lower levels in brain, kidney, liver, pancreas, placenta, and skeletal muscle.
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