Immunogen
Synthesized peptide derived from human MTDC AA range: 121-171
Specificity
This antibody detects endogenous levels of MTDC at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. [provided by RefSeq, Mar 2009],
Function
catalytic activity:5,10-methenyltetrahydrofolate + H(2)O = 10-formyltetrahydrofolate.,catalytic activity:5,10-methylenetetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH.,cofactor:Magnesium.,developmental stage:Expressed only in developing normal tissues.,miscellaneous:This NAD-dependent bifunctional enzyme has very different kinetic properties than the larger NADP-dependent trifunctional enzyme and is unique in that it requires formation of an enzyme-magnesium complex to allow binding of NAD.,similarity:Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.,subunit:Homodimer.,
Fields
>>One carbon pool by folate;>>Metabolic pathways;>>Biosynthesis of cofactors
Human protein sequence Database
P13995
Mouse protein sequence database
P18155
Rat protein sequence database
Cellular localization
Mitochondrion.
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