Immunogen
Synthesized peptide derived from human DPM3 AA range: 14-64
Specificity
This antibody detects endogenous levels of DPM3 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1：50-200. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a subunit of dolichyl-phosphate mannosyltransferase and acts as a stabilizer subunit of the dolichyl-phosphate mannosyltransferase complex. [provided by RefSeq, Jul 2008],
Function
function:Stabilizer subunit of the dolichol-phosphate-mannose synthase complex.,online information:GlycoGene database,similarity:Belongs to the DPM3 family.,subunit:Composed of three subunits; DPM1, DPM2 and DPM3. Associated with DPM1 via its C-terminal domain and with DPM2 via its N-terminal portion.,
Fields
>>N-Glycan biosynthesis;>>Metabolic pathways
Human protein sequence Database
Q9P2X0
Mouse protein sequence database
Q9D1Q4
Rat protein sequence database
Cellular localization
Endoplasmic reticulum membrane; Multi-pass membrane protein.
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