Immunogen
Synthesized peptide derived from human TRAIP AA range: 399-449
Specificity
This antibody detects endogenous levels of TRAIP at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit 1 activation that is required for cell activation and protection against apoptosis. [provided by RefSeq, Jul 2008],
Function
function:Inhibits activation of NF-kappa-B mediated by TNF.,similarity:Contains 1 RING-type zinc finger.,subunit:Binds TRAF1 and TRAF2 and is part of the receptor-TRAF signaling complex (By similarity). Interacts with CYLD.,
Gene Name
TRAIP RNF206 TRIP
Human protein sequence Database
Q9BWF2
Mouse protein sequence database
Q8VIG6
Rat protein sequence database
Cellular localization
Nucleus, nucleoplasm . Nucleus, nucleolus . Chromosome . Cytoplasm. Cytoplasm, perinuclear region . In the nucleus, found in close proximity to PCNA, suggesting localization at replication foci (PubMed:26595769). Localizes to DNA damage sites in response to replication stress (PubMed:26781088, PubMed:26595769, PubMed:26711499). .
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