Immunogen
Synthesized peptide derived from human SGPP1 AA range: 47-97
Specificity
This antibody detects endogenous levels of SGPP1 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP1 catalyzes the degradation of S1P via salvage and recycling of sphingosine into long-chain ceramides (Mandala et al., 2000 [PubMed 10859351]; Le Stunff et al., 2007 [PubMed 17895250]).[supplied by OMIM, Jun 2009],
Function
function:Has enzymatic activity against both sphingosine 1 phosphate (S1P) and dihydro-S1P. Regulates intracellular and extracellular S1P levels.,similarity:Belongs to the type 2 lipid phosphate phosphatase family.,tissue specificity:Ubiquitous, with the strongest level in placenta and kidney.,
Fields
>>Sphingolipid metabolism;>>Metabolic pathways;>>Sphingolipid signaling pathway
Human protein sequence Database
Q9BX95
Mouse protein sequence database
Q9JI99
Rat protein sequence database
Q99P55
Cellular localization
Endoplasmic reticulum membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein .
Tissue expression
Ubiquitous, with the strongest level in placenta and kidney.
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