Immunogen
Synthesized peptide derived from human CCDC6 AA range: 104-154
Specificity
This antibody detects endogenous levels of CCDC6 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the ret proto-oncogene is the cause of thyroid papillary carcinoma.[provided by RefSeq, Sep 2010],
Function
disease:A chromosomal aberration involving CCDC6 is a cause of thyroid papillary carcinoma (PACT) [MIM:188550]. Inversion inv(10)(q11.2;q21) generates the RET/CCDC6 (PTC1) oncogene.,domain:The protein has mostly an alpha helical conformation similar to myosin heavy-chain tail that might adopt a coiled-coil conformation.,subcellular location:May be a cytoskeletal protein.,tissue specificity:Ubiquitously expressed.,
Gene Name
CCDC6 D10S170 TST1
Fields
>>Pathways in cancer;>>Thyroid cancer
Human protein sequence Database
Q16204
Mouse protein sequence database
D3YZP9
Rat protein sequence database
Cellular localization
Cytoplasm. Cytoplasm, cytoskeleton . May be a cytoskeletal protein.
Tissue expression
Ubiquitously expressed.
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