Immunogen
Synthesized peptide derived from human GTR10 AA range: 233-283
Specificity
This antibody detects endogenous levels of GTR10 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the class III facilitative glucose transporter family. The encoded protein plays a role in regulation of glucose homeostasis. Mutations in this gene have been associated with arterial tortuosity syndrome.[provided by RefSeq, Dec 2009],
Function
disease:Defects in SLC2A10 are the cause of arterial tortuosity syndrome (ATS) [MIM:208050]. ATS is an autosomal recessive disorder characterized by tortuosity and elongation of major arteries, often resulting in death at young age. Other typical features include aneurysms of large arteries and stenosis of the pulmonary artery, in association with facial features and several connective tissue manifestations such as soft skin and joint laxity. Histopathological findings include fragmentation of elastic fibers in the tunica media of large arteries.,function:Facilitative glucose transporter.,similarity:Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.,tissue specificity:Widely expressed; highest levels in liver and pancreas.,
Human protein sequence Database
O95528
Mouse protein sequence database
Q8VHD6
Rat protein sequence database
Cellular localization
Endomembrane system ; Multi-pass membrane protein . Cytoplasm, perinuclear region .
Tissue expression
Widely expressed; highest levels in liver and pancreas.
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