Immunogen
Synthesized peptide derived from human ADAM2 AA range: 109-159
Specificity
This antibody detects endogenous levels of ADAM2 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded protein is a subunit of an integral sperm membrane glycoprotein called fertilin, which plays an important role in sperm-egg interactions. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013],
Function
domain:A tripeptide motif (FEE) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding.,function:Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein.,miscellaneous:In mammals, exists as a heterodimer composed of an alpha and beta subunits. In human, fertilin subunit alpha is a pseudogene.,PTM:The prodomain and the metalloprotease domain are cleaved during the epididymal maturation of the spermatozoa.,similarity:Contains 1 disintegrin domain.,similari
Human protein sequence Database
Q99965
Mouse protein sequence database
Q60718
Rat protein sequence database
Q63202
Cellular localization
Membrane; Single-pass type I membrane protein.
Tissue expression
Expressed specifically in spermatogenic cells in the seminiferous cells. Not detected in fetal tissues.
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